Blogs as a Means of Preservation Selection for the World Wide Web

Currently, there is not a strong system of selection in place when looking at preserving content on the Web. This study is an examination of the blogging community for the possibility of utilizing the decentralized and distributed nature of link selection that takes place within the community as a means of preservation selection. The purpose of this study is to compare the blog aggregators, Daypop, Blogdex, and BlogPulse, for their ability to collect content which is of archival quality. This study analyzes the content selected by these aggregators to determine if any content which is linked to most frequently for a given day is of archival quality. Archival quality is determined by comparing the content from the aggregator lists to criteria assembled for the study from a variety of archival policies and principles

Blogs as a Means of Preservation Selection for the World Wide Web

Currently, there is not a very strong system of selection in place when looking at the Web as a whole. This study is an examination of the blogging community for the possibility of utilizing the decentralized and distributed nature of link selection that takes place within the community as a means of preservation selection. The purpose of this study is to compare the blog aggregators, Daypop, Blogdex, and BlogPulse, for their ability to collect content which is of archival quality. This study analyzes the content selected by the aggregators to determine if any content which is linked most frequently for a given day is of archival quality. Archival quality is determined by comparing the content from the aggregator lists to criteria assembled for the study from a variety of archival policies and principles

Spécification formelle de systèmes complexes (méthodes et techniques)

PARIS-CNAM (751032301) / SudocSudocFranceF

Deriving Software Specifications from Event Based Models

noteresum

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

BackgroundWe previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in similar to 80% of cases.MethodsWe report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded.ResultsNo gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5-528.7, P=1.1x10(-4)) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR=3.70[95%CI 1.3-8.2], P=2.1x10(-4)). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR=19.65[95%CI 2.1-2635.4], P=3.4x10(-3)), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR=4.40[9%CI 2.3-8.4], P=7.7x10(-8)). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD]=43.3 [20.3] years) than the other patients (56.0 [17.3] years; P=1.68x10(-5)).ConclusionsRare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old